Candida glabrata endophthalmitis following penetrating keratoplasty

TitleCandida glabrata endophthalmitis following penetrating keratoplasty
Publication TypeJournal Article
Year of Publication2009
AuthorsCaldwell MC, Perfect JR, Carlson AN, Proia AD
JournalJ Cataract Refract Surg
Pagination598 - 602
Date PublishedMar
ISSN1873-4502 (Electronic) 0886-3350 (Linking)
Accession Number19251157
KeywordsAntifungal Agents / therapeutic use, Candida glabrata / *isolation & purification, Candidiasis / diagnosis / drug therapy / *microbiology, Drug Therapy, Combination, Endophthalmitis / diagnosis / drug therapy / *microbiology, Eye Infections, Fungal / diagnosis / drug therapy / *microbiology, Humans, Keratoplasty, Penetrating / *adverse effects, Lens Implantation, Intraocular, Male, Middle Aged, Phacoemulsification, Recurrence

We report a case of Candida glabrata endophthalmitis following penetrating keratoplasty in a 57-year-old man. The infection was thought to be treated successfully with intravitreal amphotericin B but flared 7 months later following cataract extraction and eventually required explantation of the intraocular lens and therapeutic keratoplasty. The literature regarding this rare infection is reviewed. Candida glabrata, an uncommon ocular pathogen, is being reported with increasing frequency and with a notable predilection for post-keratoplasty eyes. In the 10 reported cases, there is 100% concordance between host and donor tissue cultures. In half the cases, there was a latent period of several months. These infections can be difficult to treat because C glabrata is often resistant to the antifungal agents commonly used to treat Candida albicans.

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