Posttransplant lymphoproliferative disorder: significance of central nervous system involvement

TitlePosttransplant lymphoproliferative disorder: significance of central nervous system involvement
Publication TypeJournal Article
Year of Publication2005
AuthorsBuell JF, Gross TG, Hanaway MJ, Trofe J, Roy-Chaudhury P, First MR, Woodle ES
JournalTransplant Proc
Pagination954 - 5
Date PublishedMar
Accession Number15848587
KeywordsAdult, Central Nervous System / *immunology, Child, Humans, Kidney Transplantation / *immunology, Lymphoproliferative Disorders / *epidemiology, Postoperative Complications / *immunology, Registries, Retrospective Studies, United States

BACKGROUND: Few data exist regarding central nervous system (CNS) involvement in patients with posttransplant lymphoproliferative disorder (PTLD). The purpose of this study was to review the Israel Penn International Transplant Tumor Registry (IPITTR) experience with CNS involvement by PTLD. METHODS: Nine hundred ten PTLD cases from the United States were reported to the IPITTR and reviewed for CNS involvement. RESULTS: One hundred thirty-six transplant recipients with PTLD (15%) had CNS involvement. The highest incidence of CNS involvement occurred in pancreas (3 of 11; 27%) and kidney transplant recipients (76 of 429; 18%). Fifteen cases occurred in children and 121 cases in adults. For both children and adults, isolated CNS disease was associated with better survival when compared with multiple-site involvement (children: 29% vs 0%; adults: 12% vs 6%; P

Notify Library Reference ID243

Related Incidents