Transmission of clear cell tumor in a graft liver from cadaveric donor: Case report

TitleTransmission of clear cell tumor in a graft liver from cadaveric donor: Case report
Publication TypeJournal Article
Year of Publication2012
AuthorsBackes AN, Tannuri AC, de Mello ES, Gibelli NE, Andrade Wd, Tannuri U
JournalPediatric Transplantation
Volume16
Start PageE352-E355
Issue8
Date PublishedDecember
ISSN1397-3142
Accession Number00125738-201212000-00024
Keywordschildren, Clinical Medicine., complications of liver transplantation, Liver Transplantation, malignancy, pediatric liver transplantation, pediatrics.
Abstract

: Neoplasms in children after organ transplantation are related to the type and intensity of immunosuppression and the donor-recipient serostatus, especially in relation to the Epstein-Barr virus. The patient was a two-yr-old female child with biliary atresia who underwent a liver transplantation from a female cadaver donor. Two adults received kidney transplants from the same donor. Nine months after transplantation, one of the adult recipients developed an urothelial tumor in the kidney graft. Imaging tests were repeated monthly in the liver-transplanted child and revealed no abnormalities. However, one yr and two months after the transplantation, the patient developed episodes of fever. At that time, imaging and liver biopsy showed a clear cell tumor of urothelial origin in the graft and the disease was limited to the liver. The patient underwent liver retransplantation, and she is currently free of tumor recurrence. Although rare, the occurrence of tumors in the post-transplant period from cadaver donors, without previously diagnosed tumors, is one of the many problems encountered in the complex world of organ transplantation. Copyright (C) 2012 Blackwell Publishing Ltd.; References: 1. Scolfaro C, Mignone F, Gennari F, et al. Possible donor-recipient bartonellosis transmission in a pediatric liver transplant. Transplant Infect Dis, 2008: 10: 431-433. 2. Kasiske BL, Snyder JJ, Gilbertson DT, Wang C. Cancer after kidney transplantation in the United States. Am J Transplant, 2004: 4: 905-913. 3. Tyden G, Wernersson A, Sandberg J, Berg U. Development of renal cell carcinoma in living donor kidney grafts. Transplantation, 2000: 70: 1650-1656. 4. Wu CY, Hung SY, Su YT, Chang HC, Yu TJ. De novo urothelial carcinoma in a pediatric recipient of living donor kidney graft. Pediatr Transplant, 2007: 11: 811-813. 5. Schmidt R, Stippel D, Krings F, Pollok M. Malignancies of the genito-urinary system following renal transplantation. Br J Urol, 2005: 75: 572-577. 6. Kauffmam HM, Mcbride MA, Cherikh WS, Spain PC, Marks WH, Roza AM. Transplant tumor registry: Donor related malignancies. Transplantation, 2002: 74: 358-362. 7. Birkeland SA, Storm HH. Risk for tumor and other disease transmission by transplantation: A population-based study of unrecognized malignancies and other diseases in organ donors. Transplantation, 2002: 74: 1409-1413. 8. Penn I. Transmission of cancer from donor organs. Ann Transplant, 1997: 2: 7-12. 9. Pinho-Apezzato ML, Tannuri U, Tannuri AC, et al. Multiple clinical presentations of lymphoproliferative disorders in pediatric liver transplant recipients: A single-center experience. Transplant Proc, 2010: 42: 1763-1768. 10. Morath C, Schwenger V, Schmidt J, Zeier M. Transmission of malignancy with solid organ transplants. Transplantation, 2005: 80: S164-S166. 11. Buell JF, Gross TG, Woodle ES. Malignancy after transplantation. Transplantation, 2005: 80: S254-S264. 12. Stephens JK, Everson GT, Elliott CL. Fatal transfer of malignant melanoma from multiorgan donor to four allograft recipients. Transplantation, 2000: 70: 232-236. 13. Loren AW, Desai S, Gorman RC, Schuchter LM. Retransplantation of a cardiac allograft inadvertently harvested from a donor with metastatic melanoma. Transplantation, 2003: 76: 741-743. 14. Penn I. Malignant melanoma in organ allograft recipients. Transplantation, 1996: 61: 274-278. 15. Kim KK, Carmody IC, Cohen AJ, Loss GE. Donor transmission of malignant melanoma to a liver graft recipient: Case report and literature review. Clin Transplant, 2009: 23: 571-574. 16. Morris-Stiff G, Steel A, Savage P. Transmission of donor melanoma to multiple organ transplant recipients. Am J Transplant, 2004: 4: 444-446. 17. Baehner R, Magrane G, Balassanian R, et al. Donor origin of neuroendocrine carcinoma in 2 transplant patients determined by molecular cytogenetics. Hum Pathol, 2000: 31: 1425-1429.

DOI10.1111/j.1399-3046.2012.01711.x
Alternate JournalPediatr.Transplant.
Notify Library Reference ID1861

Related Incidents