Donor Derived Bacterial Infections: Report From the Disease Transmission Advisory Committee (DTAC)

TitleDonor Derived Bacterial Infections: Report From the Disease Transmission Advisory Committee (DTAC)
Publication TypeConference Paper
Year of Publication2010
AuthorsBlumberg E, Green M, Covington SG, Taranto S, Taylor K, Parker K, Chin-Hong P, DiMaio M, Gockerman JP, Green M, Hasz R, Kubak B, Lebovitz D, Pruett T, Smith A, Teperman L, Vasudev B, Nalesnik MA, Ison MG
Conference Name48th Annual Meeting of the Infectious Diseases Society of America. Vancouver, British Columbia. October 21 – 24, 2010

Background: Donor derived bacterial infections (DDBI) are an uncommon but serious complication of organ transplantation, potentially resulting in allograft loss & patient death.

Methods: The DTAC database was reviewed for cases of potential DDBI reported from 2006 to 2009. Cases were analyzed for bacterial pathogen, culture site & risk for infection, organs transplanted, antimicrobials, as well as allograft and patient outcomes. Mycobacterial infections were excluded from this analysis.

Results: 38 cases of potential DDBI were reported to DTAC. 14 cases of infection resulted in 25 recipients with transmitted DDBI. 2 donors with Ehrlichia resulted in 2/3 recipient transmission; all survived. 1 case of Legionella possibly transmitted infection to 1/6 recipients (lung only). 11 donors with pyogenic bacteria transmitted infections to 22 recipients (see Table 1); none of the affected recipients received appropriate antibiotic prophylaxis. 8 recipients expired, 2 others lost grafts; mycotic aneurysms, were common, especially with Gram negative infection. There were 16 donors with bacterial infections that did not result in transmission to 34 recipients (including 6 from pyogenic bacteria, 6 with syphilis) following receipt of appropriate antibiotics.

Conclusion: DDBI can be a significant cause of morbidity and mortality in organ transplant recipients, especially when grossly contaminated organs used or in the absence of prompt administration of appropriate prophylactic antimicrobials.

Notify Library Reference ID1838

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