Health Status and Renal Function Evaluation of Kidney Vendors: A Report from Pakistan

TitleHealth Status and Renal Function Evaluation of Kidney Vendors: A Report from Pakistan
Publication TypeJournal Article
Year of Publication2008
AuthorsNaqvi SA, Rizvi SA, Zafar MN, Ahmed E, Ali B, Mehmood K, Awan MJ, Mubarak B, Mazhar F
Date PublishedJuly
Accession Number00024798-200807000-00015
KeywordsClinical Medicine., Commercial transplant, donor follow-up, donor outcomes, kidney.

Unrelated kidney transplants have lead to commerce and kidney vending in Pakistan. This study on 104 vendors reports demographics, history, physical and systemic examination, ultrasound findings, renal and liver function and GFR by Cockcroft-Gault. Results were compared with 184 age, sex and nephrectomy duration matched living-related donors controls. Comparison of vendors versus controls showed mean age of 30.55 +/- 8.1 versus 30.65 +/- 7.85 (p = 0.91) years, M:F of 4.5:1 versus 4.2:1 and nephrectomy period of 33.89 +/- 30 versus 32.01 +/- 29.71 (p = 0.60) months respectively. Of the vendors 67% were bonded laborers earning 100 $/month. History of vendors revealed jaundice in 8%, stone disease in 2% and urinary tract symptoms in 4.8%. Postnephrectomy findings between vendors versus donors showed BMI of 21.02 +/- 2.8 versus 23.02 +/- 4.2 (p = 0.0001), hypertension in 17% versus 9.2% (p = 0.04), serum creatinine (mg/dL) of 1.17+/-0.21 versus 1.02 +/- 0.27 (p = 0.0001), GFR (mL/min) of 70.94 +/- 14.2 versus 95.4 +/- 20.44 (p = 0.0001), urine protein/creatinine of 0.150 +/- 0.109 versus 0.10 +/- 0.10 (p = 0.0001), hepatitis C positivity in 27% versus 1.0% (p = 0.0001) and hepatitis B positive 5.7% versus 0.5% (p = 0.04), respectively. In conclusion, vendors had compromised renal function suggesting inferior selection and high risk for developing chronic kidney disease in long term. Copyright (C) 2008 Blackwell Publishing Ltd.; References: 1. Evans RW, Kitzmann DJ. An economic analysis of kidney transplantation. Surg Clin North Am 1998; 78: 149-74. 2. Dew MA, Switzer GE, Goycoolea JM et al. Does transplantation produce quality of life benefits? A quantitative analysis of the literature. 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