Resolution of peanut allergy following bone marrow transplantation for primary immunodeficiency

TitleResolution of peanut allergy following bone marrow transplantation for primary immunodeficiency
Publication TypeJournal Article
Year of Publication2005
AuthorsHourihane JO, Rhodes HL, Jones AM, Veys P, Connett GJ
Date PublishedApril
Accession Number00000381-200504000-00021
KeywordsBone Marrow Transplantation, Clinical Medicine., immunodeficiency, peanut allergy.

Peanut allergy is a severe and life-threatening form of food allergy. Treatments are being developed but the mainstays of current management remain avoidance of peanut and appropriate use of rescue medication. We report the case of a boy with peanut allergy who required a bone marrow transplant (BMT) for combined immunodeficiency. A food challenge, 2 years after transplant, showed that his peanut allergy had resolved. Allergic disorders constitute a form of immune deviation and while we do not advocate BMT as a treatment for peanut allergy, we believe this case provides an insight into the basic mechanisms involved in food allergy. Copyright (C) 2005 Blackwell Publishing Ltd.; References: 1. Hourihane JO'B. Prevalence and severity of food allergy - need for control. Allergy 1998;53(Suppl. 46):84-88. 2. Grundy J, Matthews S, Bateman B, Dean T, Arshad SH. Rising prevalence of allergy to peanut in children: data from 2 sequential cohorts. J Allergy Clin Immunol 2002;110: 784-789. 3. Kagan R, Joseph L, Dufresne C, Gray-Donald K, Turnbull E, St Pierre Y et al. Prevalence of peanut allergy in primary-school children in Montreal, Canada. J Allergy Clin Immunol 2003;112: 1223-1228. 4. Agnosti JM, Sprenger JD, Lum LG, Witherspoon RP, Fisher LD, Storb R et al. Transfer of allergen-specific IgE-mediated hypersensitivity with allogeneic bone marrow transplantation. N Engl J Med 1988;319: 1623-1628. 5. Legendre C, Caillat-Zucman S, Samuel D, Morelon S, Bismuth H, Bach JF et al. Transfer of symptomatic peanut allergy to the recipient of a combined liver- and-kidney transplant. N Engl J Med 1997;337: 822-825. 6. Hourihane J, Hodges E, Smith J, Keefe M, Jones A, Connett G. Interferon-[alpha] treatment of molluscum contagiosum in immunodeficiency. Arch Dis Child 1999;80: 77-79. 7. Wahn V, Laws HJ, Bode CP, Burdach SE. Cure of latex allergy by bone marrow transplantation. Eur J Pediatr 1999;158: 88. 8. Hourihane JO'B, Roberts SA, Warner JO. Resolution of peanut allergy: case-control study. Br Med J 1998;316: 1271-1275. 9. Skolnick HS, Conover-Walker MK, Koerner CB, Sampson HA, Wood RA. The natural history of peanut allergy. J Allergy Clin Immunol 2001;107: 367-374. 10. Fleischer DM, Conover-Walker MK, Christie L, Burks AW, Wood RA. The natural progression of peanut allergy: Resolution and the possibility of recurrence. J Allergy Clin Immunol 2003;112: 183-189. 11. Gennery AR, Flood TJ, Abinun M, Cant AJ. Bone marrow transplantation does not correct the hyper IgE syndrome. Bone Marrow Transplant 2000;25: 1303-1305.

Alternate JournalAllergy
Notify Library Reference ID1802