The fate of cadaver renal allografts contaminated before transplantation

TitleThe fate of cadaver renal allografts contaminated before transplantation
Publication TypeJournal Article
Year of Publication1975
AuthorsMcCoy GC, Loening S, Braun WE, Magnusson MO, Banowsky LH, McHenry MC
Pagination467 - 472
Date PublishedDec
ISSN0041-1337; 0041-1337
Accession NumberPMID: 1108317
KeywordsAdolescent, Adult, Cadaver, Candidiasis / etiology, Enterobacteriaceae Infections / etiology, Escherichia coli Infections / etiology, Female, Graft Rejection, Humans, Kidney Transplantation, Male, Postoperative Complications / microbiology, Pseudomonas Infections / etiology, Time Factors, Transplantation, Homologous / adverse effects

Through the routine use of cultures from saline slush transport solution and the initial and final organ perfusates, 14 of 81 cadaver allografts (17.3%) were found to have been contaminated before transplantation. Gram negative organisms, cultured from 5 of the 14 contaminated allografts, resulted in the recipient's death on the first encounter with this problem and the loss of two other allografts. Early antibiotic therapy begun even without evidence of overt infection appeared to prevent any further deaths or graft loss in those whose allografts were contaminated and yielded an overall survival comparable to that of uncontaminated allografts. Without such an approach to the study of perfused cadaver allografts and the management of them when found to be contaminated, this type of infection may go undetected and contribute to allograft and patient loss.

Alternate JournalTransplantation
Notify Library Reference ID1721

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