Transmission of infection with herpes simplex virus by renal transplantation

TitleTransmission of infection with herpes simplex virus by renal transplantation
Publication TypeJournal Article
Year of Publication1987
AuthorsDummer JS, Armstrong J, Somers J, Kusne S, Carpenter BJ, Rosenthal JT, Ho M
JournalThe Journal of infectious diseases
Pagination202 - 206
Date PublishedFeb
ISSN0022-1899; 0022-1899
Accession NumberPMID: 3027191
KeywordsAdult, DNA, Viral / analysis, Female, Herpes Simplex / microbiology / transmission, Humans, Kidney Transplantation, Male, Middle Aged, Simplexvirus / genetics / isolation & purification, Transplantation, Homologous

Disseminated infection with herpes simplex virus type 2 was identified in two patients 20 days after they had received kidney transplants from the same organ donor. Neither patient had neutralizing antibody to herpes simplex virus before transplantation, and both had herpes simplex virus isolated from surveillance cultures of urine before the onset of clinical symptoms. A clear focus of primary infection was not found in either patient. Analysis of the patients' isolates by DNA restriction endonuclease analysis strongly suggested that the strains were identical. These data implicate the allografts as the source of the viral infection.

Alternate JournalJ.Infect.Dis.
Notify Library Reference ID1706

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