Transmission of mycobacterium tuberculosis via lung transplantation

TitleTransmission of mycobacterium tuberculosis via lung transplantation
Publication TypeJournal Article
Year of Publication2004
AuthorsWinthrop KL, Kubak BM, Pegues DA, Hufana C, Costamagna P, Desmond E, Sanders C, Shen P, Flores-Ibarra L, Osborne E, Bruckner D, Flood J
JournalAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Pagination1529 - 33
Date PublishedSep
Type of ArticleCase Reports
ISSN1600-6135 (Print) 1600-6135 (Linking)
Accession Number15307842
Keywords*Mycobacterium tuberculosis, California, Female, Guatemala, Humans, Lung / radiography, Lung Transplantation / *adverse effects, Middle Aged, Radiography, Thoracic, Tissue Donors, Tomography, X-Ray Computed, Tuberculosis, Pulmonary / radiography / *transmission

Organ donors are not routinely screened for tuberculosis (TB) in the United States. We investigated a case of pulmonary TB in a double-lung transplant recipient. We reviewed the donor's and recipient's records, and used molecular methods to compare the lung recipient's isolate with others from three sources: her hospital, the California state health department's genotyping database, and the donor's resident-nation of Guatemala. A respiratory specimen obtained from the lung recipient 1 day after transplantation grew Mycobacterium tuberculosis. Donor chest radiograph had a previously unnoticed pulmonary opacity that was present on post-transplant recipient chest radiographs and computed tomographs. The recipient's isolate was molecularly distinct from others at her hospital and in the state database, but was identical to two isolates from Guatemala. Tuberculosis was transmitted from lung donor to recipient. As organ transplantation becomes more common worldwide, similar cases could occur. Screening for TB in potential organ donors should be considered.

Alternate JournalAm J Transplant
Notify Library Reference ID1639

Related Incidents