Severe respiratory depression after dimethylsulphoxide-containing autologous stem cell infusion in a patient with AL amyloidosis.

TitleSevere respiratory depression after dimethylsulphoxide-containing autologous stem cell infusion in a patient with AL amyloidosis.
Publication TypeJournal Article
Year of Publication2000
AuthorsBenekli M, Anderson B, Wentling D, Bernstein S, Czuczman M, McCarthy P
JournalBone Marrow Transplant
Volume25
Issue12
Pagination1299 - 301
Date PublishedJun
ISSN0268-3369
Accession Number10871736
KeywordsAmyloidosis, Cryopreservation, Dimethyl Sulfoxide, Female, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells, Humans, Middle Aged, Respiratory Insufficiency, Transplantation, Autologous
Abstract

Adverse reactions with DMSO-cryopreserved stem cell infusion are well-recognized. However, severe, life-threatening anaphylactic reactions with DMSO are very rarely described in the literature. We report here a 58-year-old female with AL amyloidosis who developed an unexpected episode of respiratory arrest a few seconds after the beginning of thawed stem cell product infusion. Fortunately, the patient was resuscitated successfully without the need for intubation. The prompt development of the reaction just a few seconds after the stem cell infusion convincingly implicates DMSO as the potential suspect. The presence of amyloid cardiomyopathy might have also contributed to this adverse event. Bone Marrow Transplantation (2000) 25, 1299-1301.

DOI10.1038/sj.bmt.1702452
Notify Library Reference ID161

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