Glioblastoma multiforme of donor origin after renal transplantation: report of a case

TitleGlioblastoma multiforme of donor origin after renal transplantation: report of a case
Publication TypeJournal Article
Year of Publication1993
AuthorsVal-Bernal F, Ruiz JC, Cotorruelo JG, Arias M
JournalHum Pathol
Pagination1256 - 9
Date PublishedNov
Accession Number8244327
Keywords*Tissue Donors, Adult, Female, Glial Fibrillary Acidic Protein / analysis, Glioblastoma / chemistry / *etiology / pathology, Humans, Immunohistochemistry, Kidney Neoplasms / chemistry / *etiology / pathology, Kidney Transplantation / *adverse effects / pathology, Male, Middle Aged, S100 Proteins / analysis

A case of transmission of a glioblastoma multiforme from the donor to a kidney transplant recipient in the absence of previous ventriculosystemic shunt is described. The recipient was a 48-year-old woman who developed a fever with no other associated symptoms 17 months posttransplant. Physical examination revealed a large nonpulsatile mass on the upper graft pole. Histopathologic examination showed a highly cellular neoplasm with fusiform and globoid cells, a high grade of nuclear pleomorphism and mitosis, necrosis with pseudopalisading, and vascular proliferation. Immunohistochemistry of the cells showed them to contain glial fibrillary acidic and S-100 proteins, consistent with a glioblastoma multiforme. We conclude that the risk of tumor transmission from donors with primary central nervous system tumors to kidney transplant recipients, is real and should be considered when evaluating a graft mass in such patients.

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