Leukaemic transformation of engrafted bone marrow cells

TitleLeukaemic transformation of engrafted bone marrow cells
Publication TypeJournal Article
Year of Publication1985
AuthorsSmith JL, Heerema NA, Provisor AJ
JournalBr J Haematol
Pagination415 - 22
Date PublishedJul
Accession Number3893522
Keywords*Bone Marrow Transplantation, *Cell Transformation, Neoplastic, Child, Chromosomes, Human, 21-22 and Y / ultrastructure, Humans, Karyotyping, Leukemia, Lymphocytic / genetics, Leukemia, Myeloid / genetics / *therapy, Male, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.

Recurrent leukaemia following bone marrow transplantation is most often due to the regrowth of original host leukaemia cells, but may also be due to the malignant transformation of normal donor marrow cells after transplantation into a leukaemia patient. We report the ninth case of malignant change in cells of donor origin in a 12-year-old boy who was originally diagnosed as having Ph1+ CML. He remained Ph1+ during lymphoid blast crisis. After transplantation with marrow from a cytogenetically normal sister, he relapsed to Ph1- ALL in the female donor cells. The marrow showed a mixed karyotype of 46,XX/46,XX,inv(9)(p12q12). It would appear that, haematologically, the patient showed different manifestations of the same disease state. Cytogenetically, however, the pre- and post-transplant leukaemias were different.

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