Global cardiovascular risk under early corticosteroid cessation decreases progressively in the first year following renal transplantation

TitleGlobal cardiovascular risk under early corticosteroid cessation decreases progressively in the first year following renal transplantation
Publication TypeJournal Article
Year of Publication2005
AuthorsRogers CC, Alloway RR, Boardman R, Trofe J, Hanaway MJ, Alexander JW, Roy-Chaudhury P, Buell JF, Thomas M, Susskind B, Woodle ES
JournalTransplant Proc
Volume37
Issue2
Pagination812 - 3
Date PublishedMar
Accession Number15848540
KeywordsAdrenal Cortex Hormones / administration & dosage / *therapeutic use, Blood Pressure, Cardiovascular Diseases / *epidemiology, Drug Administration Schedule, Humans, Kidney Transplantation / immunology / *physiology, Lipoproteins, HDL Cholesterol / blood, Postoperative Complications / *epidemiology, Risk Assessment, Risk Factors
Abstract

A primary reason to eliminate corticosteroids from immunosuppressive regimens in solid organ transplant recipients is improved cardiovascular risk profiles. Although a number of studies have documented that corticosteroid withdrawal (CSWD) regimens reduce hypertension, hyperlipidemia, diabetes, and weight gain, global assessments of cardiovascular risk under CSWD have not been reported. The purpose of this study was to document cardiovascular risk under CSWD using a global risk assessment by Framingham risk assessment. METHODS: Framingham global cardiovascular risk assessments were performed at baseline and 3, 6, and 12 months posttransplant on patients enrolled in prospective, IRB-approved early (

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