[Herpesviruses serologic survey of corneal allograft recipients]

Title[Herpesviruses serologic survey of corneal allograft recipients]
Publication TypeJournal Article
Year of Publication2006
AuthorsRobert PY, Adenis JP, Denis F, Drouet M, Ranger-Rogez S
JournalJ Fr Ophtalmol
Pagination259 - 63
Date PublishedMar
ISSN1773-0597 (Electronic) 0181-5512 (Linking)
Accession Number16557169
Keywords*Corneal Transplantation, Adult, Aged, Aged, 80 and over, Antibodies, Viral / *blood, Cytomegalovirus / *immunology, Female, Herpesvirus 3, Human / *immunology, Herpesvirus 4, Human / *immunology, Humans, Male, Middle Aged, Prospective Studies, Simplexvirus / *immunology

AIMS: Herpesviruses are ubiquitous viruses, providing circulating antibodies in a wide range of patients. Donor-to-host transmission of Herpes simplex virus via corneal graft has been proven, leading to primary graft failure. However, the serological survey of the corneal recipient for Herpesviruses has not yet been investigated. METHODS: Circulating antibodies to HSV, VZV, CMV, and EBV were tested in 117 corneal recipients prior to surgery as well as 8 days and 3 months following surgery. Twenty-two patients had a history of corneal herpes. All patients were treated with local steroids, and no patient received systemic immunosuppressive therapy. RESULTS: No seroconversion was encountered, in particular, no CMV--patient was found CMV+ after grafting. The mean concentration of antibodies significantly decreased after grafting in a few patients. A serological profile of EBV reactivation was detected after surgery in four patients at day 8 and three more patients at 3 months. CONCLUSIONS: This study shows no significant seroconversion after grafting. However, it shows a postoperative decrease in antibody levels as well as a serological profile of EBV reactivation, possibly related to local steroids or graft immune processes.

URLinternal-pdf://Herpesvirus survey french-2038769409/Herpesvirus survey french.pdf;internal-pdf://French translation - Herpesvirus serology-3800388609/French translation - Herpesvirus serology.docx
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