Newly acquired herpes simplex virus keratitis after penetrating keratoplasty

TitleNewly acquired herpes simplex virus keratitis after penetrating keratoplasty
Publication TypeJournal Article
Year of Publication1997
AuthorsRemeijer L, Doornenbal P, Geerards AJ, Rijneveld WA, Beekhuis WH
Pagination648 - 52
Date PublishedApr
ISSN0161-6420 (Print) 0161-6420 (Linking)
Accession Number9111258
KeywordsAdult, Aged, Female, Herpes Simplex / epidemiology / *etiology, Humans, Incidence, Keratitis / pathology / *virology, Keratitis, Dendritic / virology, Keratoplasty, Penetrating / *adverse effects, Male, Middle Aged, Retrospective Studies

BACKGROUND: After penetrating keratoplasty for reasons unrelated to herpes simplex virus (HSV) keratitis, any nonspecific epithelial defect may still be caused by HSV. The purpose of this study is to determine the incidence of newly acquired herpetic keratitis and to assess contributing factors. METHODS: The authors retrospectively studied the results of 2398 penetrating keratoplasties performed between 1980 and 1995. Three typical case histories are discussed. RESULTS: Of 2112 patients in whom the primary diagnosis was not related to HSV keratitis, 18 presented with epithelial herpetic keratitis in their corneal graft. The incidence of newly acquired herpetic keratitis after penetrating keratoplasty was 1.2 per 1000 person-years. In most cases, the infection occurred in the first 2 years after the transplantation. Most often, well-known reactivating stimuli could have caused the HSV infection. CONCLUSIONS: Herpes simplex virus keratitis may develop after penetrating keratoplasty even without a clinical history of HSV in the host. Thus, HSV should be considered in the differential diagnosis of a postpenetrating keratoplasty epithelial defect. The high incidence of this infection in the first 2 years after such surgery suggests a causal relation between corneal transplantation and the HSV infection.

URLinternal-pdf://Remeijer - Newly acquired HSV keratitis-1115834881/Remeijer - Newly acquired HSV keratitis.pdf
Notify Library Reference ID1308

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