Cardiac arrest after autologous marrow infusion

TitleCardiac arrest after autologous marrow infusion
Publication TypeJournal Article
Year of Publication1991
AuthorsRapoport AP, Rowe JM, Packman CH, Ginsberg SJ
JournalBone Marrow Transplantation
Pagination401 - 3
Date PublishedMay
Type of ArticleCase Reports
ISSN0268-3369 (Print) 0268-3369 (Linking)
Accession Number2070152
KeywordsAdult, Bone Marrow Transplantation / *adverse effects, Female, Heart Arrest / *etiology, Hodgkin Disease / pathology / surgery, Humans, Pulmonary Edema / etiology, Transplantation, Autologous

A 27-year-old woman undergoing autologous bone marrow transplantation for relapsed, refractory Hodgkin's disease developed acute non-cardiogenic pulmonary edema immediately after transfusion of autologous bone marrow. A few similar cases in the literature are identified. Although the precise mechanisms for these rare reactions are not clear, several possibilities including anaphylaxis due to dimethylsulfoxide, leukoagglutination, complement activation, and transient left ventricular dysfunction are proposed and discussed. Features which might allow patients at risk for similar events to be identified include the presence of active pulmonary tumor, and a history of dyspnea and pulmonary infiltrates following transfusion of homologous blood products.

Alternate JournalBone Marrow Transplant
Notify Library Reference ID1300

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