| Title | Weighing the risks of G-CSF administration, leukopheresis, and standard marrow harvest: ethical and safety considerations for normal pediatric hematopoietic cell donors |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Pulsipher MA, Nagler A, Iannone R, Nelson RM |
| Journal | Pediatr Blood Cancer |
| Volume | 46 |
| Issue | 4 |
| Pagination | 422 - 33 |
| Date Published | Apr |
| ISSN | 1545-5009 (Print) 1545-5009 (Linking) |
| Accession Number | 16411207 |
| Keywords | *Bone Marrow Transplantation / ethics / standards, *Hematopoietic Stem Cell Mobilization / ethics / standards, *Hematopoietic Stem Cell Transplantation / ethics / standards, *Leukapheresis / ethics / standards, *Tissue Donors / classification / ethics, Child, effects, Granulocyte Colony-Stimulating Factor / *administration & dosage / adverse, Humans, Risk Assessment, Risk Factors, Safety |
| Abstract | BACKGROUND: Granulocyte colony stimulating factor (G-CSF) is used for collection of hematopoietic cells in most adult and a smaller but significant percentage of pediatric normal donor harvests. Short and long-term risks of G-CSF administration and leukopheresis are not well understood in the pediatric population. PROCEDURE: Literature review including observations from the IBMTR, NMDP, EBMT, German Donor Registry, and the authors' work. RESULTS: G-CSF causes temporary discomfort in a minority of younger donors. Rare serious side effects of G-CSF have yet to be reported in children. To date, an increase in hematological malignancies after short-term G-CSF use has not been detected in adult donors and no cases have been reported in children. Reported complications of leukopheresis in children are rare and minor, but donors |
| DOI | 10.1002/pbc.20708 |
| Notify Library Reference ID | 1291 |
