Donor transmission of malignant melanoma in a lung transplant recipient 32 years after curative resection

TitleDonor transmission of malignant melanoma in a lung transplant recipient 32 years after curative resection
Publication TypeJournal Article
Year of Publication2010
AuthorsBajaj NS, Watt C, Hadjiliadis D, Gillespie C, Haas AR, Pochettino A, Mendez J, Sterman DH, Schuchter LM, Christie JD, Lee JC, Ahya VN
JournalTranspl Int
Volume23
Issue7
Paginatione26 - 31
Date PublishedJul
ISSN1432-2277 (Electronic) 0934-0874 (Linking)
Accession Number20444242
KeywordsDonor Selection, Fatal Outcome, Female, Humans, Lung Neoplasms / *etiology, Lung Transplantation / *adverse effects, Male, Melanoma / *etiology, Middle Aged, Pulmonary Fibrosis / *surgery, Skin Neoplasms, Tissue Donors
Abstract

In the current era of organ shortages and long wait times for life-saving transplants, marginal or extended donors are increasingly being considered; one such category of marginal organs is from donors with a previous history of malignancy. Melanoma in particular has been associated with increased risk of developing late recurrence. In this report, we describe a case of fatal donor melanoma transmission to a 64-year-old lung transplant recipient 32 years after surgical excision of the melanoma. Based on this report and review of the available literature, we conclude that a history of donor melanoma, regardless of the stage and time interval from 'curative' surgical resection, should remain a strong relative contraindication to transplantation.

DOI10.1111/j.1432-2277.2010.01090.x
Notify Library Reference ID123

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