Posttransplantation de novo tumors in liver allograft recipients

TitlePosttransplantation de novo tumors in liver allograft recipients
Publication TypeJournal Article
Year of Publication1996
AuthorsPenn I
JournalLiver Transpl Surg
Pagination52 - 9
Date PublishedJan
Accession Number9346628
KeywordsAdolescent, Adult, Aged, Child, Child, Preschool, Female, Humans, Infant, Kidney Transplantation / adverse effects, Liver Transplantation / *adverse effects, Lymphoma / *etiology, Male, Middle Aged, Neoplasms / *etiology, Research Support, U.S. Gov't, Non-P.H.S., Transplantation, Homologous

De novo cancers occurred after transplantation in 8,008 organ allograft recipients, who developed 8,531 different types of malignancy. Three hundred twenty-four liver recipients developed 329 cancers. There were striking differences in the patterns of neoplasms observed when these were compared with 7,200 tumors that occurred in renal allograft recipients. Lymphomas were much more common in liver allograft recipients (57% v 12% of all tumors), whereas skin cancers (39% v 15%), carcinomas of the cervix (4% v 1%), renal tumors (4% v 1%), and vulvar carcinomas (3% v 0.6%) were more common in renal allograft recipients. The high incidence of lymphomas is related partly to the more intense immunosuppressive therapy administered to hepatic allograft recipients and partly to the large percentage of pediatric patients among them. The intense immunosuppression also accounts for the much shorter induction times of lymphomas (mean, 15 v 46 months; P

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