| Title | Epidemiologic study on the origin of cancer after kidney transplantation |
| Publication Type | Journal Article |
| Year of Publication | 2004 |
| Authors | Pedotti P, Poli F, Longhi E, Frison S, Caldara R, Chiaramonte S, Gotti E, Marchini F, Maresca C, Sandrini S, Scalamogna M, Taioli E |
| Journal | Transplantation |
| Volume | 77 |
| Issue | 3 |
| Pagination | 426 - 8 |
| Date Published | 42036 |
| ISSN | 0041-1337 (Print) 0041-1337 (Linking) |
| Accession Number | 14966419 |
| Keywords | Adult, Cohort Studies, Female, Humans, Male, Middle Aged, Neoplasms / epidemiology / *etiology / genetics, Organ Transplantation / *adverse effects, Tandem Repeat Sequences, Tissue Donors |
| Abstract | BACKGROUND: Subjects who underwent solid organ transplantation are at higher risk for a wide variety of cancers. METHODS: The authors investigated the origin of cancer in a cohort of 2,526 patients followed up for 60.7 +/- 35.6 months after kidney transplantation between 1990 and 2000 in seven transplant centers. RESULTS: One hundred four of them developed cancer. All subjects who developed solid cancer within 6 months after transplantation (n=10) and a group of subjects who developed solid cancer after 6 months posttransplant (n=10) were selected. Short tandem repeat analysis was performed on paraffin-embedded biopsy specimens of tumors and on both donor and recipient pretransplant peripheral blood. Biologic material was obtained in 17 of the 20 selected patients (85.0%). The analysis showed that 16 of 17 tumors were genetically identical to the recipient. CONCLUSIONS: The authors' results suggest that donor transmission of solid cancer is an unlikely event in their population. |
| DOI | 10.1097/01.TP.0000111757.08499.C2 00007890-200402150-00020 [pii] |
| Notify Library Reference ID | 1153 |
