| Title | Cytogenetics and bone marrow transplantation |
| Publication Type | Journal Article |
| Year of Publication | 1986 |
| Authors | Palka G, Di Bartolomeo P, Iacone A, Di Girolamo G, Betti S, Calabrese G, Natale D, Stuppia L, Rieve AK, Torlontano G |
| Journal | Cancer Genet Cytogenet |
| Volume | 21 |
| Issue | 2 |
| Pagination | 147 - 57 |
| Date Published | 42064 |
| Accession Number | 3512073 |
| Keywords | *Bone Marrow Transplantation, *Chromosome Aberrations, Acute Disease, Adolescent, Adult, Anemia, Aplastic / genetics / therapy, Bone Marrow / ultrastructure, Child, Child, Preschool, Female, Graft Survival, Hematologic Diseases / genetics / *therapy, Humans, Karyotyping, Leukemia / genetics / therapy, Leukemia, Myeloid / genetics / therapy, Male, Middle Aged, Recurrence, Research Support, Non-U.S. Gov't, Time Factors |
| Abstract | The authors report hematologic and cytogenetic data on 19 patients treated with allogeneic bone marrow transplantation (BMT) for severe hematologic disorders: 8 patients with chronic myelogenous leukemia, 6 with acute leukemia, 3 with severe aplastic anemia, 1 with refractory anemia, and 1 with beta-thalassemia major. Cytogenetic assays were performed on marrow cells before conditioning, 30 days after BMT, and at subsequent times. The authors discuss the role of cytogenetic studies in the evaluation of bone marrow engraftment, leukemic transformation of the graft, and disease relapse. |
| Notify Library Reference ID | 1125 |
