Cytogenetic survey of 31 patients treated with bone marrow transplantation for acute nonlymphocytic and acute lymphoblastic leukemias

TitleCytogenetic survey of 31 patients treated with bone marrow transplantation for acute nonlymphocytic and acute lymphoblastic leukemias
Publication TypeJournal Article
Year of Publication1991
AuthorsPalka G, Calabrese G, Di Girolamo G, Stuppia L, Di Bartolomeo P, Guanciali Franchi P, Di Virgilio C, Bianchi GP, Angrilli F, Parruti G
JournalCancer Genet Cytogenet
Volume51
Issue2
Pagination223 - 33
Date PublishedFeb
Accession Number1993307
Keywords*Bone Marrow Transplantation, Adolescent, Adult, Child, Child, Preschool, Female, Humans, Karyotyping, Leukemia, Lymphocytic, Acute / *genetics, Leukemia, Nonlymphocytic, Acute / *genetics, Male, Research Support, Non-U.S. Gov't
Abstract

The authors report on a sequential cytogenetic study carried out on 31 patients with acute leukemia (20 with acute lymphoblastic leukemia and 11 with acute non-lymphocytic leukemia) who underwent bone marrow transplantation (BMT). Engraftment was documented in all patients with sex-mismatched donors and with donor constitutional aberrations. During the follow-up, ranging from 6 to 110 months, clinical and hematologic relapse was observed in 11 patients (35.5%). Five of these cases showed a normal karyotype, 3 were of undefined relapse origin, 2 were aneuploid karyotypes, and one was donor (male) metaphases. Cytogenetic and immunologic data in the latter patient were suggestive of relapse in donor cells.

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