| Title | Cytogenetic survey of 31 patients treated with bone marrow transplantation for acute nonlymphocytic and acute lymphoblastic leukemias |
| Publication Type | Journal Article |
| Year of Publication | 1991 |
| Authors | Palka G, Calabrese G, Di Girolamo G, Stuppia L, Di Bartolomeo P, Guanciali Franchi P, Di Virgilio C, Bianchi GP, Angrilli F, Parruti G |
| Journal | Cancer Genet Cytogenet |
| Volume | 51 |
| Issue | 2 |
| Pagination | 223 - 33 |
| Date Published | Feb |
| Accession Number | 1993307 |
| Keywords | *Bone Marrow Transplantation, Adolescent, Adult, Child, Child, Preschool, Female, Humans, Karyotyping, Leukemia, Lymphocytic, Acute / *genetics, Leukemia, Nonlymphocytic, Acute / *genetics, Male, Research Support, Non-U.S. Gov't |
| Abstract | The authors report on a sequential cytogenetic study carried out on 31 patients with acute leukemia (20 with acute lymphoblastic leukemia and 11 with acute non-lymphocytic leukemia) who underwent bone marrow transplantation (BMT). Engraftment was documented in all patients with sex-mismatched donors and with donor constitutional aberrations. During the follow-up, ranging from 6 to 110 months, clinical and hematologic relapse was observed in 11 patients (35.5%). Five of these cases showed a normal karyotype, 3 were of undefined relapse origin, 2 were aneuploid karyotypes, and one was donor (male) metaphases. Cytogenetic and immunologic data in the latter patient were suggestive of relapse in donor cells. |
| Notify Library Reference ID | 1124 |
