First report of invasive amebiasis in an organ transplant recipient.

TitleFirst report of invasive amebiasis in an organ transplant recipient.
Publication TypeJournal Article
Year of Publication1997
AuthorsPalau LA, Kemmerly SA
Pagination936 - 7
Date PublishedSep
Accession Number9326427
KeywordsAdult, Animals, Antiprotozoal Agents, Colon, Colonoscopy, Dysentery, Amebic, Entamoeba histolytica, Humans, Immunity, Cellular, Immunosuppressive Agents, Intestinal Mucosa, Liver Transplantation, Male, Metronidazole, Postoperative Complications, T-Lymphocytes

T-cell mediated immunity is an important defense mechanism against amebiasis. However, organ transplant recipients with severe T-cell immunosuppression are not at increased risk of having Entamoeba histolytica invasive disease. The reasons are unclear and probably multifactorial, but it is likely that the absence of intestinal colonization with pathogenic strains in countries where transplants occur and the judicious intake of possible contaminated food and water are important contributing factors. We describe the first report of a liver transplant recipient with severe E. histolytica colitis who was successfully treated with metronidazole without modifying his immunosuppression therapy.

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