HTLV-I-associated myelopathy manifested after renal transplantation

TitleHTLV-I-associated myelopathy manifested after renal transplantation
Publication TypeJournal Article
Year of Publication2000
AuthorsNakatsuji Y, Sugai F, Watanabe S, Kaido M, Koguchi K, Abe K, Sakoda S
JournalJ Neurol Sci
Volume177
Issue2
Pagination154 - 6
Date PublishedAug 15
ISSN0022-510X (Print) 0022-510X (Linking)
Accession Number10980313
KeywordsHumans, Immunosuppressive Agents / adverse effects, Kidney Failure, Chronic / surgery, Kidney Transplantation / *adverse effects, Male, Middle Aged, Paraparesis, Tropical Spastic / *pathology / transmission
Abstract

We report a patient with HTLV-I-associated myelopathy (HAM), who developed symptoms of myelopathy 4 years after cadaveric renal transplantation. Since he was seronegative before the transplantation, it is suggested that HTLV-I infection was transmitted via renal graft transplantation. He has been treated with immunosuppressive agents such as cyclosporin A (CsA), mycophenolate mofetil (MMF), and prednisolone (PSL) to prevent graft rejection. This case suggested that these immunosuppressive agents are poorly effective in suppressing either the onset or progression of HAM/TSP.
DOI
Notify Library Reference ID1065

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