Recurrence of acute leukemia in donor cells after bone marrow transplantation: documentation by in situ DNA hybridization

TitleRecurrence of acute leukemia in donor cells after bone marrow transplantation: documentation by in situ DNA hybridization
Publication TypeJournal Article
Year of Publication1993
AuthorsMouratidou M, Sotiropoulos D, Deremitzaki K, Spathas DH, Hoffbrand AV, Prentice HG, Papanastasiou K, Tsakanikas S, Tsaftaridis P, Stamatelou M
JournalBone Marrow Transplant
Volume12
Issue1
Pagination77 - 80
Date PublishedJul
Accession Number8374538
KeywordsAdolescent, Antigens, Neoplasm, Bone Marrow Transplantation / *adverse effects, DNA Probes, DNA, Neoplasm / *genetics, Female, Humans, In Situ Hybridization, Leukemia, CALLA-Positive / genetics / immunology, Leukemia, Myelocytic, Acute / genetics / immunology / *surgery, Male, Recurrence, Tissue Donors, Y Chromosome
Abstract

Donor cell leukemia after BMT has been documented in a small number of cases mainly by cytogenetic studies. We describe a case of leukemia relapse in a 16-year-old girl 1 year after BMT from her histocompatible brother. Relapse in donor cells was initially suspected on the basis of cytogenetic analysis and confirmed by DNA in situ hybridization in blast cells using a Y chromosome-specific probe.

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