Infections Transmitted by Transplantation

TitleInfections Transmitted by Transplantation
Publication TypeJournal Article
Year of Publication2010
AuthorsMorris MI, Fischer SA, Ison MG
JournalInfectious Disease Clinics of North America
Pagination497 - +
Date PublishedJun
Type of ArticleArticle
Accession NumberISI:000278466600013
Keywordsblood-donors, bone-marrow-transplantation, chagas-disease, Donor screening, Donor-derived infection, hepatitis-c virus, human-immunodeficiency-virus, liver-transplantation, Organ transplant, solid-organ transplantation, transmission, trypanosoma-cruzi, united-states, us, west-nile-virus

Infections are frequently transmitted through solid-organ and, to a lesser extent, stem cell transplantation. There are 2 major types of donor-derived infections that are transmitted: those that would be expected secondary to donor and recipient screening (ie, transmission of cytomegalovirus, Epstein-Barr virus, or toxoplasmosis from a seropositive donor to a seronegative recipient) and those that are unexpected despite routine donor screening (ie, human immunodeficiency virus and hepatitis C virus transmitted from a seronegative donor). Expected transmissions occur frequently and screening and prophylaxis strategies are applied to at-risk individuals in nearly all transplant centers globally. Several high profile donor-derived infectious disease transmissions have been recognized; these reports have raised awareness of this rare complication of transplantation. Issues related to the epidemiology of, screening for, and management of proven or probable donor-derived infections are reviewed in this article.

Alternate JournalInfect. Dis. Clin. North Am.
Notify Library Reference ID1042

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