Toxoplasmosis in pediatric recipients of heart transplants

TitleToxoplasmosis in pediatric recipients of heart transplants
Publication TypeJournal Article
Year of Publication1992
AuthorsMichaels MG, Wald ER, Fricker FJ, del Nido PJ, Armitage J
JournalClin Infect Dis
Pagination847 - 51
Date PublishedApr
ISSN1058-4838 (Print) 1058-4838 (Linking)
Accession Number1576279
Keywords*Heart Transplantation, Adolescent, Child, Preschool, Female, Humans, Immunosuppression, Male, Postoperative Complications / *etiology, Toxoplasmosis / *etiology, Toxoplasmosis, Cerebral / etiology

Toxoplasma gondii has long been recognized as a potential cause of severe disease in the congenitally infected infant and the immunocompromised host. This report describes three children with toxoplasmosis after heart transplantation and reviews the cases of 18 adult recipients of cardiac transplants (reported in the English-language literature) who developed toxoplasmosis postoperatively. Onset of disease was within the first 6 1/2 months following transplantation. Severity ranged from asymptomatic seroconversion to myocardial infiltration or disseminated neurological disease and death. Only one patient was known to be seropositive for antibody to T. gondii prior to transplantation. Transmission was most likely via the donor organ. Seronegative patients who receive organs from seropositive donors are at high risk for serious disease; prophylactic strategies need to be developed.

Notify Library Reference ID1014

Related Incidents