Status:
Ready to upload
Record number:
1645
Adverse Occurrence type:
MPHO Type:
Time to detection:
4 months - 12 years
Alerting signals, symptoms, evidence of occurrence:
Eleven new cases (8 renal and 3 liver transplants) of visceral leishmaniasis diagnosed between 1992 and 2003 in three academic hospital centres in the South of France. Clinically, the main symptoms were fever, splenomegaly, weight loss and hepatomegaly. Leucopenia and anemia were also frequent.
Demonstration of imputability or root cause:
Direct finding of the parasite in smears of bone marrow, liver biopsy (for liver recipients), PCR, positive serology. Eleven different cases are described, imputability changes accordingly.
Groups audience:
Keywords:
References:
Suggest references:
[4001] Fernández-Guerrero ML et al. Visceral leishmaniasis in immunocompromised patients with and without AIDS: a comparison of clinical features and prognosis. Acta Tropica 2004; 90: 11-16
Note:
Add Leishmania to the adverse occurrence taxonomy (Evi)
Expert comments for publication:
There is the possibility of donor derived infection even in hypoendemic areas as southern Europe, for example. In this paper, the different routes of infection (i.e. donor derived infection, already infected recipient prior to surgery or infection acquired in the post-transplant period) have not been explored by the authors that focus primarily on the clinical presentation in the recipients.