Severe hemolytic transfusion reaction due to anti-A1 following allogeneic stem cell transplantation with minor ABO incompatibility.

TitleSevere hemolytic transfusion reaction due to anti-A1 following allogeneic stem cell transplantation with minor ABO incompatibility.
Publication TypeJournal Article
Year of Publication2013
AuthorsAkkok CA, Haugaa H, Galgerud A, Brinch L
JournalTransfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis//Transfus Apheresis Sci
Volume48
Issue1
Pagination63 - 6
Date Published2013
ISBN Number1473-0502
Other Numbers101095653
Keywords*Anemia, Hemolytic/im [Immunology], *Blood Group Incompatibility/im [Immunology], *Stem Cell Transplantation/mt [Methods], Anemia, Hemolytic/bl [Blood], Anemia, Hemolytic/et [Etiology], Hemolysis/im [Immunology], Humans, Male, Middle Aged, Transplantation, Homologous/mt [Methods]
Abstract

Blood components should be compatible both with the recipient and the donor in the ABO incompatible allogeneic stem cell transplantation setting. A patient with blood type A2 received peripheral blood stem cells from a blood type O donor. The patient was in critical condition due to treatment-related toxicity. He had acquired anti-A1 that was unfortunately overlooked. Following transfusion of A1 red blood cells in error, he developed a severe hemolytic transfusion reaction. Anti-A1 is rarely clinically significant. We discuss the role of passenger lymphocytes in development of the anti-A1, and stress the importance of investigating unusual/atypical reactions in blood typing.Copyright © 2012 Elsevier Ltd. All rights reserved.
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