Status:
Ready to upload
Record number:
1639
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Rare
Time to detection:
24 hours
Alerting signals, symptoms, evidence of occurrence:
An AHTR has its onset within 24 hours of a transfusion. Clinical or laboratory features of hemolysis are present. Common signs of AHTR are: fever, chills/rigors, facial flushing, chest pain, abdominal pain, back/flank pain, nausea/vomiting, diarrhea, hypotension, pallor, jaundice, oligoanuria, diffuse bleeding, dark urine. Common laboratory features are: hemoglobinemia, hemoglobinuria, decreased serum haptoglobin, unconjugated hyperbilirubinemia, increased LDH and AST levels, decreased hemoglobin levels. Not all clinical or laboratory features are present in cases of AHTR.
Demonstration of imputability or root cause:
Clinical or laboratory features of hemolysis are present along with serological evidence for the presence of the antibody including elution of antibody from red cells. Antibodies to high frequency antigens include anti-Vel, anti-Yt(a), anti-Co(a), anti-H, anti-AnWj, anti-Kx, anti-MAM, anti-Ku, anti-Lan, anti-Lu8, anti-Tj(a) (PP1Pk), ABTI, Emm
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
References:
Suggest new keywords:
high frequency antigens anti-Vel, anti-Yt(a), anti-Co(a), anti-H, anti-AnWj, anti-Kx, anti-MAM, anti-Ku, anti-Lan, anti-Lu8, anti-Tj(a) (PP1Pk), ABTI, Emm
Reference attachment:
Suggest references:
- Poole, J. and Daniels, G. (2007). Blood group antibodies and their significance in transfusion medicine. Transfus Med Rev 21(1): 58-71.
- Arndt, P.A. and Garratty, G. (2004). A retrospective analysis of the value of monocyte monolayer assay results for predicting the clinical significance of blood group alloantibodies. Transfusion 44(9):1273-1281.
Expert comments for publication:
Rare antibodies to the high-frequency antigens, can cause severe intravascular hemolytic transfusion reactions.