Status:
Ready to upload
Record number:
1630
Adverse Occurrence type:
MPHO Type:
Time to detection:
5 days
Alerting signals, symptoms, evidence of occurrence:
Five days after 4 units of packed RBC, the patient developed generalized joint pain and fever of 39°C. Her Hb level dropped from 12.0 g/dL to 9.3 g/dL and the unconjugated bilirubin level rose to 27 mmol/L. She was jaundiced and had hemoglobinuria.
Demonstration of imputability or root cause:
An RBC alloantibody with specificity to the Rh system (anti-c, titer 1:16.384) was identified by the indirect antiglobulin test. The Rh phenotype of the RBC used in the last packed RBC transfusion was CcDEe. The patient’s RBC phenotype was CDe.
Imputability grade:
2 Probable
Groups audience:
Keywords:
References:
Reference attachment:
Suggest references:
Fabron, A, Jr., Moreira, G, Jr. and Bordin, JO. (1999). Delayed hemolytic transfusion reaction presenting as a painful crisis in a patient with sickle cell anemia. Sao Paulo medical journal = Revista paulista de medicina 117:38-9
Note:
OK ONCE THE REFERENCE IS INDEXED (EVI)
Expert comments for publication:
Rh (D) antibodies often have the capacity to cause severe immediate or delayed extravascular hemolytic transfusion reactions and all Rh antibodies should be considered to be potentially clinically significant. Rh antibodies include: D, C, C(w), E, c, e, e(8), Ce, f, Go(a), G, V (Rh 10), Rh17, Rh29, RH19.