Acute Hemolytic Transfusion Reaction (AHTR), anti-P antibodies

Status:

Ready to upload

Record number:

1601

Adverse Occurrence type:

Acute Hemolytic Reaction

MPHO Type:

Red blood cells

Time to detection:

within 24 hours

Alerting signals, symptoms, evidence of occurrence:

Clinical or laboratory features of hemolysis are present. Common signs of AHTR are: fever, chills/rigors, facial flushing, chest pain, abdominal pain, back/flank pain,nausea/vomiting,diarrhea, hypotension, pallor, jaundice, oligoanuria, diffuse bleeding, dark urine. Common laboratory features are: hemoglobinemia, hemoglobinuria, decreased serum haptoglobin, unconjugated hyperbilirubinemia, Increased LDH an AST levels, decreased hemoglobin levels. Not all clinical or laboratory features are present in cases of AHTR. P antibodies include: P, P +P(1)+P(k), anti-Tj(a) and P1.

Demonstration of imputability or root cause:

Clinical or laboratory features of hemolysis are present along with serological evidence for the presence of the antibody including elution of antibody from red cells.

Imputability grade:

3 Definite/Certain/Proven

Groups audience:

Clinical complications

Keywords:

AHTR (acute hemolytic transfusion reaction)

References:

Blood group antibodies and their significance in transfusion medicine.

Suggest new keywords:

P, P +P(1)+P(k), anti-Tj(a), P1, LKE

Reference attachment:

* Antibodies, Poole, 2007.pdf

Suggest references:

Poole, J and Daniels G. (2007). Blood group antibodies and their significance in transfusion medicine. Transfus Med Rev 21(1): 58-71.

Expert comments for publication:

Anti-P and -PP1Pk are naturally occurring antibodies invariably present in individuals with the very rare Pk and p phenotypes. LKE is related to the P antigens and is a high incidence antigen.