Status:
Ready to upload
Record number:
1598
Adverse Occurrence type:
MPHO Type:
Time to detection:
within 24 hours
Alerting signals, symptoms, evidence of occurrence:
Clinical or laboratory features of hemolysis are present. Common signs of AHTR are: fever, chills/rigors, facial flushing, chest pain, abdominal pain, back/flank pain, nausea/vomiting, diarrhea, hypotension, pallor, jaundice, oligoanuria, diffuse bleeding, dark urine. Common laboratory features are: hemoglobinemia, hemoglobinuria, decreased serum haptoglobin, unconjugated hyperbilirubinemia, Increased LDH an AST levels, decreased hemoglobin levels. Not all clinical or laboratory features are present in cases of AHTR.
Demonstration of imputability or root cause:
Clinical or laboratory features of hemolysis are present along with serological evidence for red cell antibodies including elution of antibodies from the patient's red cells. Anti-Kell antiodies include: K, k, Ku, K11, K19, Kx + Km, Kx, Kp(a), Kp(b), Js(a), Js(b).
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
Suggest new keywords:
K, k, Ku, K11, K19, Kx + Km, Kx, Kp(a), Kp(b), Js(a), Js(b)
Reference attachment:
Suggest references:
Poole, J. and Daniels, G. (2007). Blood group antibodies and their significance in transfusion medicine. Transfus Med Rev 21(1):58-71.
Expert comments for publication:
In the Kell system, anti-K, -k, and -Ku have caused severe immediate hemolytic transfusion reactions. All other Kell antibodies should be considered to have the potential to cause hemolytic transfusion reaction, although these are likely to be delayed. The most commonly encountered immune antibodies are D > K> E> Fya> Jka.