Record to update:
MPHO Type:
Estimates Frequency:
extremely rare event of DCL in SCT (risk of DCL moderately higher than in general population)
Time to detection:
38 months in median (ragen 5-167): wide range of occurence (intermediate).
Alerting signals, symptoms, evidence of occurrence :
Signs of AML, CML or Myelodysplasia in reciepient; majority was myeloid.
Donors did not show leukemia (at least during short term follow up - for long term this is unknown); further no relation to condioning, donor, graft manipulation, GVHD prophylaixs, complication identified. Probably only surveillance is helpful (which was not expressed as this in word in the text)
Demonstration of imputability or root cause:
FISH analysis or other molecular techniques: olymorphism markers (VNTR/STR)
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Note:
This Survey & Review of the EBMT included 7 cases published and 7 new cases of leukemia in donor cell (DCL) after allogenic stemm cell transplantation(period: 12/1982-09/2003). In this review only the 7 unpublished cases will be evaluated for avoiding doubeling of reports.
Suggest new keywords:
allogenic stem cell transplantation
Donor cell leukemia
Adverse occurrence description:
new cases of leukemia in donor cell (DCL) after allogenic stem cell transplantation
Suggest references:
see referecne 666: Hertenstein B, et al. Development of leukemia in donor cells after allogeneic stem cell transplantation--a survey of the European Group for Blood and Marrow Transplantation (EBMT); Haeamtolgica/the haematolgoy journal 2005;90: 969-975