Status:
Ready to upload
Record number:
1426
Adverse Occurrence type:
MPHO Type:
Time to detection:
10 days
Alerting signals, symptoms, evidence of occurrence:
HHV6 DNA detected in serum (up to 200.000 copies/ml). Despite antiviral treatment, HHV-6 copy numbers remained unchanged. Asymptomatic.
Demonstration of imputability or root cause:
Chromosomal integration of the HHV-6 genome (CIHHV-6) was suspected. HHV-6 DNA was detectable in donor lymphocytes (PCR). FISH analysis of peripheral blood leukocytes of the patient and of donor lymphocytes demonstrated integration of HHV-6 DNA in all analyzed cells at the telomere region of the short arm of one homologue of chromosome 17 (ter 17p).
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
References:
Suggest references:
Strenger V, Urban C, Schwinger W, Nacheva EP, Aberle SW. Transmission of chromosomally integrated HHV-6 by bone marrow transplantation. Pediatr Blood Cancer. 2011 Jan;56(1):171.
Note: