Status:
Ready to upload
Record number:
1374
Adverse Occurrence type:
MPHO Type:
Time to detection:
N/A
Alerting signals, symptoms, evidence of occurrence:
A case of a 38-year-old HIV-positive female patient who developed fulminant hepatic failure of an autoimmune etiology with rapid deterioration of her clinical status and secondary multiorgan failure and, therefore, needed emergency liver transplantation (LT) as a lifesaving procedure. Because of the scarcity of organs and the high mortality rate for emergency status patients on the LT waiting list, it was decided to accept a T. cruzi-seropositive deceased donor liver graft for this immunocompromised T. cruzi-seronegative patient.
Demonstration of imputability or root cause:
The recipient had a rapid postoperative recovery and was discharged on postoperative day 9 without prophylactic treatment for Chagas disease. Fifteen months after LT, she was still alive and had never experienced seroconversion on periodic screening tests for T. cruzi detection.
Groups audience:
Keywords:
Reference attachment:
Suggest references:
Goldaracena, N., Wolf, M.M., Quinonez, E., Anders, M., Mastai, R. and McCormack, L. (2012). Is it safe to use a liver graft from a Chagas disease-seropositive donor in a human immunodeficiency virus-positive recipient? A case report addressing a novel challenge in liver transplantation. Liver Transpl 18(8): 979-983.
Note:
donor disease without documented transmission