Acute Hemolytic Transfusion Reaction (AHTR), anti-Wr

Status:

Ready to upload

Record number:

1263

Adverse Occurrence type:

Acute Hemolytic Reaction

MPHO Type:

Red blood cells

Estimated frequency:

Case Report

Time to detection:

85 minutes

Alerting signals, symptoms, evidence of occurrence:

Following the transfusion, patient had bilirubin and urobilinogen in his urine and a fall in haemoglobin of nearly 2 g dL (-1).

Demonstration of imputability or root cause:

Clinical and serology results.

Imputability grade:

3 Definite/Certain/Proven

Groups audience:

Clinical complications

Keywords:

bilirubin elevation

RBC (red blood cell)

acute hemolysis

AHTR (acute hemolytic transfusion reaction)

References:

An acute haemolytic transfusion reaction caused by anti-Wr.

Suggest new keywords:

anti-Wr, Diego

Reference attachment:

* AHTR Wra, Cherian, 2007.pdf

Suggest references:

Cherian. G., Search, S., Thomas, E., Poole, J., Davies, S.V. and Massey, E. (2007). An acute haemolytic transfusion reaction caused by anti-Wr. Transfus Med 17(4):312-314.

Expert comments for publication:

Anti-Wra of the Diego system, a relatively common antibody to an antigen of very low frequency, has caused severe hemolytic transfusion reactions. It has also been implicated in delayed hemolytic transfusion reactions.