Acute Hemolytic Transfusion Reaction (AHTR), anti-A2

Status:

Ready to upload

Record number:

1260

Adverse Occurrence type:

Acute Hemolytic Reaction

MPHO Type:

Red blood cells

Estimated frequency:

Case Report

Time to detection:

1 hour

Alerting signals, symptoms, evidence of occurrence:

Patient with blood group B was incorrectly transfused with a unit of A2 group red blood cells, and developed clinical and immunohematologic reactions; patient was treated with eculizumab, but hemoglobinemia and hemoglobinuria was present several hours after transfusion.

Demonstration of imputability or root cause:

Hemoglobinuria, hemoglobemia, transient increased bilirubin.

Imputability grade:

2 Probable

Groups audience:

Clinical complications

Keywords:

hemoglobinemia

hemoglobinuria

red blood cell transfusion

blood transfusion

bilirubin elevation

AHTR (acute hemolytic transfusion reaction)

References:

Successful use of eculizumab for treatment of an acute hemolytic reaction after ABO-incompatible red blood cell transfusion.

Suggest new keywords:

anti-A2, acute hemolytic transfusion reaction (AHTR),

Reference attachment:

* AHTR A2, Weinstock, 2014.pdf

Suggest references:

Weinstock, C., Mohle, R., Dorn, C., Weisel, K., Hchsmann, B., Schrezenmeier, H. and Kanz, L. (2014). Successful use of eculizumab for treatment of an acute hemolytic reaction after ABO-incompatible red blood cell transfusion, Transfusion 55(3):605-610. DOI: 10.1111/trf.12882;