Autoimmune thrombocytopenia

Status:

Ready to upload

Record number:

1278

Adverse Occurrence type:

Autoimmune

MPHO Type:

Marrow

Estimated frequency:

Very common. Poly factorial, GvHD and viral with 11 of 26 viral related to CMV.

Time to detection:

60 - 649 days

Alerting signals, symptoms, evidence of occurrence:

Prolonged thrombocytopenia characterized as up to 60 days post transplant; Late thrombocytopenia characterized as initial recovery and then thrombocytopenia after 60 days post transplant.

Demonstration of imputability or root cause:

Positive for platelet associated IgG

Imputability grade:

3 Definite/Certain/Proven

Groups audience:

Clinical complications

Keywords:

CBPAb (cell bound antiplatelet antibody)

CMV (cytomegalovirus)

GvHD (graft versus host disease)

IgG (immunoglobulin G)

References:

Autoimmune-like thrombocytopenia after bone marrow transplantation.

Graft-v-host disease is associated with autoimmune-like thrombocytopenia.

Suggest new keywords:

autoimmune, thrombocyopenia, bone marrow, rrow biopsy, CBPAb (cell bound antiplatelet antibody), CMV (cytomegalovirus), GVHD (graft versus host disease), IgG (immunoglobulin G)

Reference attachment:

* Autoimmune, Cahn, 1989.pdf

Suggest references:

- Cahn, JY, et al, 1989. Autoimmune-like thrombocytopenia after bone marrow transplantation. Blood 74:2771. - Anasetti C1, Rybka W, Sullivan KM, Banaji M, Slichter SJ., Graft-v-host disease is associated with autoimmune-like thrombocytopenia. Blood. 1989 Mar;73(4):1054-8.

Note:

To index also the second reference provided (Evi)

Expert comments for publication:

Post transplant development or (donor derived) thyroid disease is well described.