Status:
Ready to upload
Record number:
1168
Adverse Occurrence type:
MPHO Type:
Time to detection:
18 days
Alerting signals, symptoms, evidence of occurrence:
Fever, elevated blood pressure, anemia with very high RBC transfusion requirement. Low Hb, raised LDH and Bilirubin.
Demonstration of imputability or root cause:
On Day 18 after transplantation, the immunohematologic screening revealed a positive DAT (C3d 3+) and an alloanti-Jka. Hemolysis in the patient at that time was indicated by a drop in the Hb and an increase in the LDH level (maximum, 592 IU/L on Day 23).
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
Suggest new keywords:
hemolytic anemia
anti-Jk(a)
Reference attachment:
Suggest references:
Leo, A., Mytilineos, J., Voso, M. T., Weber-Nordt, R., Liebisch, P., Lensing, C., Schraven, B. 2000. Passenger lymphocyte syndrome with severe hemolytic anemia due to an anti-Jk(a) after allogeneic PBPC transplantation. Transfusion 40:632-6.
Note:
cannot upload until a new selection of "Other" is added to sequence at: Harm to a recipient > Immunological complications > Detrimental immunization > (Other)
Expert comments for publication:
Kidd antibodies, anti-Jka, -Jkb, and -Jk3, have been responsible for severe and fatal immediate and delayed reactions.