Record number:
1055
Adverse Occurrence type:
MPHO Type:
Time to detection:
3 days
Alerting signals, symptoms, evidence of occurrence:
80 year old male patient with multile co-morbidities including COPD and MDS was admitted with symptomatic refractory anemia; he received 2 units of RBC and presented to hospital 3 days later with fever, polyarthralgia, headache. Treated for a possible bacterial chest infection and on day 2 of admission developed leucopenia and thrombocytopenia; infection with DENV2 was confirmed by PCR in blood. Dengue IgM was negative. Donor did not have symptoms before or after donation and was tested retrospectively; plasma viral load was 1.35E+08 RNA copies/ml
Demonstration of imputability or root cause:
Donor and recipient infecting strains were sequenced with 100% identity over 1485 base pairs accross the envelope gene of DENV2. The sequence was different from other viruses circulating at the time in the region where the recipient lived. Donor was from a different geographical area in Puerto Rico.
Imputability grade:
3 Definite/Certain/Proven
Keywords:
Suggest references:
Stramer SL, Linnen JM, Carrick JM, Foster GA, Krysztof DE, Zou S, et al. Dengue viremia in blood donors identified by RNA and detection of dengue transfusion transmission during the 2007 dengue outbreak in Puerto Rico. Transfusion. 2012;52(8):1657-66.