Record number:
1051
Adverse Occurrence type:
MPHO Type:
Time to detection:
2 days
Alerting signals, symptoms, evidence of occurrence:
Patient with diabetes mellitus, chronic renal failure, chronic heart disease and other co-mobidities, received a red blood cell transfusion following a coronary artery by-pass. On day +2 he developed fever, malaise and hepatitis, worsening of thrombocytopenia and worsening of pleural effusion. DENV-2 detected in blood by PCR. Treated supportively, recovered. Seroconverted to dengue IgG and IgM.
Demonstration of imputability or root cause:
Asymptomatic repeat donor at time of donation, reported fever and myalgia 1 day post donation. DENV-2 detected in blood by PCR. Three recipients of blood components (RBC, platelets, FFP) from same donation were diagnosed with DENV- 2 infection within 2 days from transfusions.
Imputability grade:
3 Definite/Certain/Proven
Keywords:
References:
Suggest references:
Tambyah, P.A., Koay, E.S., Poon, M.L., Lin, R.V., and Ong, B.K. (2008). Dengue hemorrhagic fever transmitted by blood transfusion. N Engl J Med 359:1526-27.
Teo, D., Ng, L.C. and Lam, S.(2009). Is dengue a threat to the blood supply? Transfu Med 19(2): 66-77.