Record number:
1149
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Up to 70% of liver transplant (LT) recipients
Time to detection:
12 - 36 months
Alerting signals, symptoms, evidence of occurrence:
92 consecutive LT recipients for whom prospectively stored frozen sera were available for autoantibodies assessment by immunofluorescence were evaluated. Antinuclear (ANA), antismooth muscle (ASMA), and anti liver–kidney microsomal type 1 (anti-LKM) in up to 70% of the liver transplant recipients.
Demonstration of imputability or root cause:
Patients had previously tested negative became autoantibody positive after grafting. Patients with graft dysfunction had a significantly higher autoantibody prevalence irrespective of the etiology of liver injury as compared to those patients with persistently normal liver biochemistry.
Imputability grade:
2 Probable
Keywords:
Suggest references:
Foschi, A., Zavaglia, C.A., Fanti, D., Mazzarelli, C., Perricone, G., Vangeli, M., Vigano, R. and Belli. L.S. (2015). Autoimmunity after liver transplantation: a frequent event but a rare clinical problem. Clin Transplant DOI 10.1111/ctr.12498.