Record number:
1061
Adverse Occurrence type:
MPHO Type:
Time to detection:
2 weeks
Alerting signals, symptoms, evidence of occurrence:
Fever 37.9 *C progressing to elevated AST and ALT and hepatitis with microabscesses requiring ventilatory support. Treatment with acyclovir and IVIG successful, recipient seroconverted 5 weeks after initial primary HSV diagnosis.
Demonstration of imputability or root cause:
Recipient PCR levels of HSV DNA >10.4 log (10) copies/mL. Liver biopsy samples showed necrotic areas with inflammatory infiltrates with "glassy" nuclei around the necrotic areas. Immunoperoxidase staining and PCR of the biopsy tissue was positive for HSV. Pretransplant donor positive, recipient negative. Other sources of infection could not be ruled out and matching between viruses was not performed.
Imputability grade:
2 Probable
Keywords:
Suggest references:
Midani AA, Pinney J, Field N, et al. Fulminant hepatitis following primary herpes simplex virus infection in renal transplant recipients.Saudi Journal of Kidney Diseases and Transplantation. 2011; 22(1); 107-111.