Record number:
688
Adverse Occurrence type:
MPHO Type:
Alerting signals, symptoms, evidence of occurrence:
Graft failure. No apparent cause, unresponsiveness to corticosteroids, no recent history of a rejection episode
Demonstration of imputability or root cause:
Grafts with insufficient endothelial cells developed late endothelial failure. The main cause of graft failure after the first 5 postoperative years
Accounts for over 90% of failures between 5 and 10 years after PK. Can be elicited by complications during follow up (previous ocular hypertension, rejection episodes, etc.), therefore not easily attributable to tissues properties.
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