Record number:
558
Adverse Occurrence type:
MPHO Type:
Time to detection:
10 months
Alerting signals, symptoms, evidence of occurrence:
Transmission of HCV. Co-transmission with HIV to multiple recipients by multiple organs. Lab Results: HIV ab positive, low to low normal HIV viral loads, low CD4 cell counts, HCV ab negative high viral loads.
Demonstration of imputability or root cause:
Genetic sequences were highly related between between HCV and HIV strains infecting all 4 recipients, confirming transmission from a common donor. HCV in sera of all recipients was genotype 1a. HIV gag and evn sequence from donor and recipients were identical except for a single nucleotide difference found in liver recipient. Donor was negative for HCV and HIV by serology; had engaged in MSM behavior.
Imputability grade:
3 Definite/Certain/Proven
Keywords:
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