Record number:
431
Adverse Occurrence type:
MPHO Type:
Time to detection:
2 years
Alerting signals, symptoms, evidence of occurrence:
Subacute myelopathy. Analysis was performed of serum samples from a multiorgan donor and the five recipients. Two years after transplantation, three organ recipients positive for antibodies to HTLV-I were detected (two kidney transplants and one liver). All the recipients' serum samples were negative at the time of transplantation except those from the multiorgan donor.
Demonstration of imputability or root cause:
HTLV-I DNA sequences were recovered, amplified, and sequenced from all the samples from the HTLV-I-positive recipients and the donor's mother. The homology of HTLV-I sequences was 100% in all cases.
Imputability grade:
3 Definite/Certain/Proven
Keywords:
References:
Suggest references:
aaa