Status:
Ready to upload
Record number:
253
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
The Council of Europe does not deal with germ cell cancer as a category but has more generalized guidelines for testicular and ovarian cancers, as well as CNS germ cell tumors.
- Most recent risk assessment for testicular cancer (Council of Europe, 2025):
Testicular cancer diagnosed during procurement: Testicular cancer diagnosed at retrieval is considered an absolute contraindication to donation.
Testicular cancer in donor history: Given the good treatment response of testicular cancer in general and stage 1 cancers in particular, a stage 1 cancer with at least 5 years recurrence-free follow-up is likely to be associated with minimal risk. For other stages a higher transmission risk should be assumed, but risk will decrease with recurrence-free time and increasing probability of cure.
- Most recent risk assessment for ovarian cancer (Council of Europe, 2025):
Ovarian cancer diagnosed during donor procurement: Ovarian cancer is considered an unacceptable risk for organ donation.
Ovarian cancer in the donor history: Treated ovarian cancer is considered high-risk for organ donation. Depending on initial stage, grade, therapy and duration of recurrence-free survival (> 5 years), the risk category might decrease for some individuals.
Alerting signals, symptoms, evidence of occurrence:
Not specified.
Demonstration of imputability or root cause:
Condition present in the donor. More than one recipient affected from the same donor.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
Suggest new keywords:
Registry series
Deceased donor
Kidney transplant
Liver transplant
Germ cell tumor, other or type not specified
Suggest references:
aaa
Expert comments for publication:
Two kidney and one liver recipient all developed donor cancer related to a single donor with germ cell tumor not further specified (Tables 1 and 2). This is part of a series of donor tumor transmissions reported by the Spanish National Transplant Organization (ONT) Tumor Registry