Case report: Choriocarcinoma (2010)

Record number:

Adverse Occurrence type:

MPHO Type:

Estimated frequency:

Most recent risk assessment for choriocarcinoma (Council of Europe, 2022): Due to the high transmission and mortality rates, it is considered an unacceptable risk for organ donation in any stage of disease. History of choriocarcinoma: Due to the reported high transmission and mortality rates, it is considered to be associated with a high or unacceptable risk for transmission through organ donation, depending on the recurrence-free period prior to donor death.

Time to detection:

1 month

Alerting signals, symptoms, evidence of occurrence:

Increased Human Chorionic Gonadotropin (hCG) levels and intestinal tumor suggesting a metastasis. No histology reported..

Demonstration of imputability or root cause:

Condition known in the donor. She was a 26-year-old pregnant woman who died from a cerebral hemorrhage initially attributed to a vascular malformation. Histological examination demonstrated the presence of a placental choriocarcinoma three weeks after donation. More than one recipient affected from the same donor with elevated HCG levels.

Imputability grade:

2 Probable

Groups audience:

Malignancy

Keywords:

choriocarcinoma

liver

hCG (human chorionic gonadotropin)

vascular malformation

histological examination

placental choriocarcinoma

intestinal metastasis