| Title | ABO-incompatible allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning: close association with transplant-associated microangiopathy |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Worel N, Greinix HT, Leitner G, Mitterbauer M, Rabitsch W, Rosenmayr A, Hocker P, Kalhs P |
| Journal | Transfus Apher Sci |
| Volume | 36 |
| Issue | 3 |
| Pagination | 297 - 304 |
| Date Published | Jun |
| ISSN | 1473-0502 (Print) 1473-0502 (Linking) |
| Accession Number | 17569587 |
| Keywords | ABO Blood-Group System / *immunology, Adolescent, Adult, Aged, Blood Group Incompatibility / *complications, Female, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation / *adverse effects / methods, Humans, Male, Microcirculation, Microvessels / pathology, Middle Aged, Peripheral Vascular Diseases / *etiology / therapy, Plasma Exchange, Risk Factors, Transplantation Conditioning / *methods, Transplantation, Homologous, Treatment Outcome, Young Adult |
| Abstract | Transplant-associated microangiopathy (TAM) is a severe complication following allogeneic hematopoietic stem cell transplantation (HSCT) even after reduced-intensity conditioning (RIC). Data on 112 patients following RIC were analyzed with respect to TAM according to the ASBMT and risk factors, response to well-defined therapy and outcome were determined. TAM occurred in 11 of 112 patients. Univariate analysis determined acute graft-versus-host disease and ABO-incompatibility as risk factors for TAM. Treatment consisted of withdrawal of calcineurin inhibitors and plasma exchange (PE). Response to PE was 64%. PE seems to be an effective therapeutic option that should be assessed in larger patient cohorts. |
| DOI | 10.1016/j.transci.2007.03.004 |
| Notify Library Reference ID | 1655 |
